Vitamin A isn't like the sun, if you apply during the day may be ineffective or irritate the skin. Cream with this ingredient should be applied at night, its better. However, the retinol cream can do both day and night, but the night would be better.
People with dry skin problems or allergic, you should test for allergic reaction before and apply moisturizer to moisturizing supplements after using the reduce wrinkles cream, because retinol in the vitamin A can cause dry skin more easily and can cause acne in some people.
The retinol cream can cause acne in some people.
Some brands may advertise that wrinkle creams contain amino acids and peptide, which is a new innovation of the cosmetic industry that it has to do research then believe it to be able to remove wrinkles as well. This information is not yet clear whether it really works or not. Because in vitro research, it does not mean that it will work in human. But the side effects, it also does not have any obvious effect (Meaning it is not found or just started in a small group). This is up to the consumer to find information of product.
